Abstract

The present study investigates the anti-ulcer activity of Sphagneticola trilobata plant extract in an alcohol-induced gastric ulcer model in rats. Gastric ulcers, a common gastrointestinal disorder, are often exacerbated by alcohol consumption. This research aims to evaluate the protective effects and potential mechanisms of Sphagneticola trilobata, a plant known for its medicinal properties, against gastric mucosal damage. Rats were administered alcohol to induce gastric ulcers and subsequently treated with Sphagneticola trilobata extract. Gastric lesions were assessed macroscopically to determine ulcer index, and other relevant parameters. Results indicated a significant reduction in ulcer formation and improvement in gastric mucosal integrity in treated groups compared to controls. These findings suggest that Sphagneticola trilobata extract possesses considerable anti-ulcerogenic properties, making it a promising candidate for further pharmacological studies.

Keywords

• Anti-ulcer activity,
• Sphagneticola trilobata,
• Gastric ulcer,
• Alcohol-induced,
• Rats

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