Abstract

Levothyroxine therapy is given when deficient in the thyroid hormone is found in the human body. Many circumstances physiological or quasi-physiological or clear pathologically, can modify the absorption of levothyroxine in the human body. Levothyroxine intake may actually vary by age and patient compliance, fasting, consumption of certain foods from (fibre, grapes, soybeans, papaya, coffee, etc.) or some medicines (proton pump inhibitors, antacids, sucralfate, etc.) Cetera). In addition, there can be many gastrointestinal illnesses, including conditions and illnesses that disrupt the integrity of the intestinal barrier. Anything that affects stomach acid can alter the bioavailability of levothyroxine. Because it's the huge widespread prevalence of thyroid disease, large many patients face such problems. Therefore, forming the new levothyroxine oral preparations other than solid tablets represent an interesting therapeutic approach at the same time, simple and potent to face this problem. Recently, two different levothyroxine were introduced formulations are proposed: liquid and soft gel formulations. Such prescriptions are innovative and effective an inexpensive therapeutic approach for patients with hypothyroidism with mal-absorption problems levothyroxine. ⁽⁴⁴⁾

Keywords

• Levo-thyroxine; Absorption; Mal-absorption; Liquid formulation; pre-formulating

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