Abstract

The study aimed to develop and assess a topical Niosomal gel formulation of NSAIDs to enhance drug delivery, improve therapeutic efficacy, and reduce adverse effects. Niosomes, a vesicular carrier system, were used to encapsulate and deliver the NSAID topically, improving drug retention and penetration. The Niosomal gel was characterized by its particle size, zeta potential, drug entrapment efficiency, stability, and rheological properties. The in vitro release kinetics and skin permeation and retention studies were conducted using in vitro and ex vivo models. The results showed that the developed topical Niosomal gel formulation provided controlled drug release, enhanced skin permeation, and improved drug retention compared to conventional gels. These findings suggest the potential utility of Niosomal gel formulations for localized NSAID delivery, offering improved therapeutic outcomes while minimizing systemic side effects.

Keywords

• Niosomal Gel Formulation,
• Enhance Drug Delivery,
• Improve Therapeutic Efficacy,
• Vesicular Carrier System,
• Drug Entrapment Efficiency

References

• Chien, Y.W., (2005). Novel Drug Delivery Systems, 2nd edition, Revised and Expanded, Marcel Dekker, INC, New York, 1.
• Uchegbu, I. F., & Florence, A. T. (1995). Non-ionic surfactant vesicles (niosomes): physical and pharmaceutical chemistry. Advances in colloid and interface science, 58(1), 1-55.
• Murdan, S. (1998). Non-ionic surfactant-based organogels: their structures and potential as vaccine adjuvants. University of London, University College London (United Kingdom).
• Lasic, D. D. (1990). On the thermodynamic stability of liposomes. Journal of colloid and interface science, 140(1), 302-304.
• Biswal.S., Murthy P.N., (2008). Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential. Int. J. Pharm. Sci. & Nanotech. 1(1), 1-8.
• Alamayehu Tarekejen., Nisha M Joseph., (2010). Niosomes in targeted drug delivery: Some recent advances. Int. J. Pharm. Sci. & Res. 1(9), 1-8.
• Madhav NVS., Saini A., (2011).Niosomes: A Novel Drug Delivery System. Int. J. Res.Pharm. & Chem. 1(3), 498-511
• Jia-You Fang., Ying-Yue Wang., Wen- Ta Chiu., (2001). Effect of liposomes and niosomes on skin permeation of Enoxacin. Int.J.Pharm 219, 61-72.
• Pratap S.Jadon., Rajesh S.Jadon., Virendra Gajbhiye., (2009). Enhanced oral bioavailability of Griseofulvin via Niosomes. AAPS. Pharm. Sci. Tech. 10(4), 1186- 1192.
• Vijay Prakash pandey., Karthikeyan Deivasigamani.,(2009). Preparation and Characterization of ofloxacin non-ionic surfactant vesicles for ophthalmic use. J.Pharm.Res. 2(8), 1330-1334.
• Malay K.Das., Narahari N Palei., (2011). Sorbitan ester niosomes for topical delivery of Rofecoxib.Ind.J.Exp.Bio. 49,438-445.
• Jong Soo Woo., Chul Soon Yong., Jong oh Kim., (2009). Formulation and invitro assessment of Minoxidil niosomes for enhanced skin delivery.Int.J.Pharm. 377, 1-8.
• Gurrapu., Raju Jukanti., Sharan Reddy Bobbala., (2011). Improved oral delivery of Valsartan from maltodextrin based proniosome powders.Adv.Powder.Tech. 30, 1-8.
• Ismail A.Attia., Sanna A.El-Gizawy., Medhat A.Fouda.,(2007). Infuence of a Niosomal formulation on oral bioavailability of Acyclovir in Rabbits. AAPS.Pharm.Sci.Tech. 8(4), E1-E7.
• Pandey Shivanand., (2010). Development and characterization of Cefpodoxime proxetil Niosomes. Int.J.Pharma World. Res. 1(3) 1-11.
• Indu Pal Kaur., Shilpa Kakkar., (2011). Spanlastics-A novel nanovesicular carrier system for ocular delivery.Int.J.Pharm. 413,202-210.
• Naresh, R. R., Pillai, G. K., Udupa, N., & Chandrashekar, G. (1994). Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats. Indian Journal of Pharmacology, 26(1), 46-48.
• Guinedi, A. S., Mortada, N. D., Mansour, S., & Hathout, R. M. (2005). Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide. International journal of pharmaceutics, 306(1-2), 71-82.
• Ghada Abdelbary., Nashwa El-gendy.,(2008). Niosomes-Encapsulated Gentamicin for Ophthalmic controlled delivery.AAPS.Pharm.Sci.Tech.2008, 9(3), 740-747.
• Arora Rajnish., Sharma Ajay.,(2010). Release studies of Ketoprofen niosomes formulation.J.Chem.Pharm.Res.2(1),79-82.
• Ruckmani, K., Jayakar, B., & Ghosal, S. K. (2000). Nonionic surfactant vesicles (niosomes) of cytarabine hydrochloride for effective treatment of leukemias: encapsulation, storage, and in vitro release. Drug development and industrial pharmacy, 26(2), 217-222.
• Gyanendra Singh., Harinath Dwivedi., Rakesh Pundir., (2010). Targeted Delivery of Rifampicin by Niosomal Drug Delivery System.J.Pharm.Res. 3(5), 1152-1154.
• Agarwal.A., Katare.O.P., Vyas.S.P., (2001). Preparation and in-vitro evaluation of Liposomal/Niosomal delivery systems for antipsoriatic drug Dithranol. Int.J.Pharm. 228, 43-52.
• Manosroi. A., Jantrawut.p., Manosroi.J., (2008). Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with Diclofenac diethylammonium. Int.J.Pharm. 360,156-163.
• Sankar V., Ruckmani K., (2009). Niosome drug delivery system: Advances and Medical Applications – An overview. Pharmacology online, 2, 926-932.
• Abdul Ahad., Asgar Ali., Mohamed Aqil., (2011). Formulation and Evaluation of nano transfer somes using experimental design technique for accentuated transdermal delivery of Valsartan.J.Nano.Med. 30, 1-13.

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