Abstract

The meroterpene bakuchiol has lately generated a lot of buzz in the beauty and medicine sectors. Although it has a wide geographical range, the seeds of the medicinal plant Psoralea corylifolia, which is native to Asia, are its principal source. Nevertheless, the low seed germination rates and significant seedling mortality put this therapeutic plant in jeopardy. Here, research documenting plant regeneration from root fragments is highlighted in a review paper. Then, because it looks so much like other species, we talk about and investigate a method that may be used to check if the plant is real and stop forgeries. We also provide a "green" extraction approach for bakuchiol and investigate potential chemical synthesis methods for bakuchiol. In addition, we detail the several biological functions of bakuchiol, focusing on those that affect the skin. Antifungal, antibacterial, antioxidant, anti-inflammatory, antiaging, depigmenting, and anticancer are some of bakuchiol's primary skin bioactivities. Nevertheless, novel skin delivery techniques that enable bakuchiol's encapsulation are necessary and advantageous due to its unique physicochemical characteristics. This review article also provides a thorough description of systems that are micro- or nano-sized and have medicinal or cosmetic uses. The use of bakuchiol in cosmetic and dermopharmaceutical formulations raises regulatory, metabolic, and toxicological problems that impact both the user and the environment. The dermatological uses of bakuchiol, a chemical isolated from Psoralea corylifolia, are discussed in detail in this article. Because of its antioxidant, anti-inflammatory, and anti-aging capabilities, bakuchiol has attracted interest as a possible natural substitute for retinol. Here we take a look at its molecular features, extraction techniques, and safety profiles. Also covered are the effects of bakuchiol on acne, hyperpigmentation, and wrinkles, among other dermatological issues. All things considered, the data show that bakuchiol may be a powerful and adaptable component in skincare products, which is great news for the development of all-natural skincare options.

Keywords

• Bakuchiol,
• Psoralea Corylifolia,
• Dermatological

References

• Cariola, A., El Chami, M., Granatieri, J., & Valgimigli, L. (2023). Anti-tyrosinase and antioxidant activity of meroterpene bakuchiol from Psoralea corylifolia (L.). Food Chemistry, 405, 134953.
• Uikey, S. K., Yadav, A. S., Sharma, A. K., Rai, A. K., Raghuwanshi, D. K., & Badkhane, Y. (2010). The botany, chemistry, pharmacological and therapeutic application of Psoralea corylifolia L.-A review. International Journal of Phytomedicine, 2(2).
• Shaikh, H. S., & Shaikh, S. S. (2021). Babchi (Psoralea corylifolia): From a variety of traditional medicinal application to its novel roles in various diseases: A review. Asian Journal of Pharmacy and Technology, 11(3), 238-244.
• Alalaiwe, A., Hung, C. F., Leu, Y. L., Tahara, K., Chen, H. H., Hu, K. Y., & Fang, J. Y. (2018). The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption. European Journal of Pharmaceutical Sciences, 124, 114-126.
• Khushboo, P. S., Jadhav, V. M., Kadam, V. J., & Sathe, N. S. (2010). Psoralea corylifolia Linn.—“Kushtanashini”. Pharmacognosy reviews, 4(7), 69.
• Attri, S., Singh, A., Rashid, F., Singh, S., Mohana, P., Alshehri, S., ... & Arora, S. (2023). Targeting JAK/STAT signaling pathway and anti-inflammatory markers using bakuchiol isolated from Psoralea corylifolia for cytotoxicity of human squamous cell carcinoma (A431) cells. Journal of King Saud University-Science, 35(6), 102716.
• Mahajan, N., Koul, B., Gupta, P., Shah, B. A., & Singh, J. (2022). Psoralea corylifolia L.: Panacea to several maladies. South African Journal of Botany, 149, 963-993.
• Chopra, B., Dhingra, A. K., Grewal, A. S., Jain, A., Chaudhary, J., & Grover, P. (2023). Bakuchiol: A Potential Anticancer Compound from Psoralea corylifolia Linn. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 23(9), 989-998.
• Koul, B., Taak, P., Kumar, A., Kumar, A., & Sanyal, I. (2019). Genus Psoralea: a review of the traditional and modern uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 232, 201-226.
• Alam, F., Khan, G. N., & Asad, M. H. H. B. (2018). Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review. Phytotherapy Research, 32(4), 597-615.
• Jafernik, K., Halina, E., Ercisli, S., & Szopa, A. (2021). Characteristics of bakuchiol-the compound with high biological activity and the main source of its acquisition-Cullen corylifolium (L.) Medik. Natural Product Research, 35(24), 5828-5842.
• Chaudhuri, R. K., Sivamani, R., Jagdeo, J. R., Elsner, P., & Maibach, H. I. (2015). Bakuchiol: a retinol-like functional compound, modulating multiple retinol and non-retinol targets. Cosmeceuticals and Active Cosmetics. 3rd ed. Boca Raton: Taylor & Francis Group, 1-8.
• Qin, T., Liu, J., Bi, Y., Wang, Y., Liu, J., & Ding, G. (2023). Improved extraction efficiency of bakuchiol with antioxidant and whitening bioactivities from the seeds of Psoralea corylifolia L. Science of Traditional Chinese Medicine, 1(2), 123-128.
• Chen, L., Chen, S., Sun, P., Liu, X., Zhan, Z., & Wang, J. (2023). Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics. Chinese Medicine, 18(1), 1-38.
• Singh, S., & Agrawal, A. Ethnopharmacological, Phytochemistry and Pharmacological Activities of Psoralea Corylifolia: A Review.
• Patel, K., Kumar, V., Verma, A., Rahman, M., & Kumar Patel, D. (2019). Health benefits of furanocoumarins ‘Psoralidin’an active phytochemical of Psoralea Corylifolia: The present, past and future scenario. Current Bioactive Compounds, 15(4), 369-376.
• Belge, D. A., & Jeurkar, M. M. (2023). MORPHOLOGICAL, PHARMACOLOGICAL AND TOXICOLOGICAL PROFILE OF PSORALEA CORYLIFOLIA L: A REVIEW.
• Mj, A., Singh, T. R., & Patgiri, B. J. (2015). Anti microbial activity of different dosage forms of Bakuchi (Psoralea corylifolia Linn.) taila, an Ayurvedic formulation. International Journal of Ayurvedic Medicine, 6(3), 232-236.
• Jha, A., Pokharel, B., Patel, B. P., & Chaudhary, R. D. (2023). Traditional and Contemporary uses, Phytochemistry and Pharmacology of Psoralea corylifolia Linn. Journal of Ayurveda Campus, 4(1).
• Dhaliwal, S., Rybak, I., Ellis, S. R., Notay, M., Trivedi, M., Burney, W., ... & Sivamani, R. K. (2019). Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology, 180(2), 289-296.
• Zhao, Y., Cheng, C., Gao, Y., & Wang, J. (2023). Integrative Review on the Chemical Components, Pharmacology and Toxicology of Psoralea Corylifolia L.(Bu Gu Zhi). Future Integrative Medicine, 2(1), 36-47.
• Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol‐like functional compound revealed by gene expression profiling and clinically proven to have anti‐aging effects. International journal of cosmetic science, 36(3), 221-230.
• Ribeiro, M. S. M. (2022). Internship Reports and Monograph Entitled" Skin applications of bakuchiol–a review" (Master's thesis).
• Lim, S. H., Ha, T. Y., Ahn, J., & Kim, S. (2011). Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. Phytomedicine, 18(5), 425-430.
• Msebele, B. (2019). Application of Sutherlandia flutescens in cosmetic skin industry (phytochemical fingerprinting and its activity against skin immune diseases.

This work is licensed under a Creative Commons Attribution 4.0 International License.